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Stefanos Theoharis, Ph.D., Targeted Cancer Immunotherapy - TGF-B2 Inhibitor Trabedersen
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oncology focused biotech company, Corporate Information
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Private investors
Venture capital funds
, Investors
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survival, leukaemia, myeloma, Only limited improvement over the last 40 years for some cancers
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Chemotherapy, Targeted Therapy, Immunotherapy, High-grade glioma,
Pancreatic cancer, Malignant melanoma
, Targeted immunotherapy is the 3rd generation of cancer treatments
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cancer indications, unmet medical need, High-grade glioma,
Pancreatic Carcinoma, Malignant melanoma , Investigated cancer indications with high unmet medical need
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TGF-B2, Immunosuppression, Metastasis, Angiogenesis, Tumor Growth
, TGF-B2 has multi-modal cancer-promoting effects
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Monoclonal Antibodies, Small Molecule Inhibitors, Antisense,
Efficacy, Specificity, Safety, A successful anti-TGF-B2 campaign must fulfill a number of key criteria
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Antisense Technology, Cancer protein, Nascent, Nucleus, pathogenic protein, Antisense molecules
, Antisense Technology
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Trabedersen, Antisense Molecules, Exceptional Efficacy Downregulation, Low COGS , Antisense efficiently downregulates protein synthesis at the translational level
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Trabedersen, Clinical Phase, indications , Trabedersen is in advanced clinical development in various indications with very high unmet need
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Trabedersen, survival benefit, Phase IIb, Anaplastic Astrocytoma
, AA patients treated with Trabedersen have 17.4 months survival benefit
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Trabedersen, survival rate, AA patients treated with Trabedersen show doubled 24-month survival rate
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GBM subgroup, prognostic parameters, Trabedersen , Three-fold survival rate in GBM subgroup with the prognostic parameters < 55 yrs, KPS > 80%
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survival benefit, pancreatic cancer patients, Trabedersen, Phase II study
, Significant survival benefit expected in pancreatic cancer patients treated 2nd line with Trabede
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Preliminary results, malignant melanoma, Ipilimumab, Preliminary results of P001 study showing high potential for Trabedersen in malignant melanoma
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business opportunity, risk reward ratio, Market potential, Proof of concept , Unique business opportunity with promising risk/reward ratio
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clinical efficacy, indications, High-grade glioma,
Pancreatic cancer, Malignant melanoma , Summary: trabedersen shows impressive clinical efficacy and outcome in several indications