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Dr. Arndt Schottelius, Antibodies
, Morphosys: Optimizing Antibodies to Fight Cancer: MOR208 as a New Approach in B-cell Malignancies
00:30
Pipeline, antibody library HuCAL, Diagnostics, Financial Strength,
Management Team, MorphoSys: Overview
01:25
Sales, Antibody Product Sales, biological drugs, toxicity, indications, generics, Why Antibodies?
02:41
Naked Antibodies, Antibodies with optimized Fc part, Bi-/Tri-functionalAntibodies
, Approaches to
03:47
MOR208 (XmAb®5574), B-cell Malignancies, CD19, Xencor, , MOR208 (XmAb(R) 5574) as a New Approach in B-cell Malignancies
04:40
B Cell Malignancies, leukemias, lymphomas, acute lymphoblastic, sales , Some Facts About B Cell Malignancies
06:00
Anti-tumor Mechanisms, IgG – Fc Receptor Interactions, mAb activity, NK cell, Enhanced ADCC, phagocytosis by macrophages, Anti-tumor Mechanisms are Mediated by IgG - Fc Receptor Interactions
07:18
B-cell Malignancies, Anti-CD19 Antibodies, clinical data, NHL, ALL, B-cell depletion in lymphoma , Anti-CD19 Antibodies Hold Promise for the Treatment of B-cell Malignancies
08:05
Efficacy, FcyR, xenograft, Ramos, , Efficacy Against Established Tumors is FcyR-Dependent and Enhanced by Fc Engineering
09:04
MOR208 XmAb5574, Cynomolgus Monkeys, MOR208/XmAb5574 Showed Rapid and Sustained Depletion of B cells in Cynomolgus Monkeys
09:46
MOR208 XmAb5574, Potent ADCC, Patient-Derived B-CLL Cells, MOR208/XmAb5574 Induces Potent ADCC Against Patient-Derived B-CLL Cells
10:54
MOR208, CD19 Antibody, safety, Fc domain modification of MOR208 , MOR208 is Competitive in the CD19 Antibody Space
11:50
MOR208 – Ongoing Phase 1 Trial, Design, Population, Clinical Data, trials
, MOR208 - Ongoing Phase 1 Trial
12:48
Antibody Pipeline, programs, Novartis, Roche, Pfizer
, MorphoSys's Antibody Pipeline - One of the Broadest in the Industry