00:00
Resminostat, 4SC AG: Dr. Ulrich Dauer, CEO, 4SC AG presents, Resminostat
00:32
Forward looking statements, Forward looking statements
00:40
revenue, research collaborations, investors, cash reserves, Market cap, Liquid assets, Phase IIb study, oncology, 4SC at a glance
02:02
Pipeline, Product, Indication, Mode, Preclinical, Phase I, Phase II, Phase III, Vidofludimus, A broad and value-focused Pipeline
02:40
Resminostat, Oncology, Resminostat - A innovative epigenetic therapeutic option in oncology
03:05
press release, JANUARY 19, 2012: Pressemitteilung
03:40
Efficacy Assessment, JANUARY 19, 2012: Efficacy Assessment
04:10
chart, JANUARY 19, 2012: Chart Data
04:35
HCC, Therapy, liver cancer, 2ND LINE THERAPY, Liver cancer (HCC): high medical need
05:58
DNA, Epigenetics, About Epigenetics: why our DNA isn't our destiny
07:05
HDACs, DRUG TOLERANCE, EPIGENETIC MODIFICATION, apoptosis, SHELTER RATIONALE: HDACs PROMOTE DRUG TOLERANCE THROUGH EPIGENETIC MODIFICATION
08:53
EPIGENETIC HDAC-INHIBITION, RESMINOSTAT, Sorafenib, , SHELTER RATIONALE: RE-SENSITISATION THROUGH EPIGENETIC HDAC-INHIBITION WITH RESMINOSTAT
09:29
PHASE II, STUDY DESIGN, HCC, PHASE II
10:35
SHELTER, PRIMARY ENDPOINT MET (PFSR),
Progression Free Survival (PFS) Rates and PFS, SHELTER: PRIMARY ENDPOINT MET (PFSR)
11:18
SHELTER: PROGRESSION FREE SURVIVAL (4.6 MONTHS),
Mono Therapy, Combination, , SHELTER: PROGRESSION FREE SURVIVAL (4.6 MONTHS)
11:32
SHELTER CONCLUSION: SURVIVAL BENEFIT INDICATED, Placebo,
Sorafenib, SHELTER CONCLUSION: SURVIVAL BENEFIT INDICATED
12:32
approval, launch, Phase II PoC, Exploratory, Road to approval - 1st launch possible in 2016/17
13:21
Resminostat, Yakult HonSHa, License Agreement, Hepatocellular carcinoma, irinotecan and oxaliplatin, Resminostat - Yakult HonSHa Partner for Japan
14:14
Clinical Development Strategy, Phase I, INDICATIONS, Hodgkin‟s Lymphoma, Hepatocellular Carcinoma, Colorectal Cancer, monotherapy, Resminostat: Clinical Development Strategy
14:53
4SC Outlook, milestones, ACHIEVEMENTS, MILESTONES, Initiate Phase IIb, , 4SC Outlook: achieved & upcoming milestones